Wednesday, May 6, 2020
ââ¬ÅIt is not in the stars to hold our destiny but in...
ââ¬Å"It is not in the stars to hold our destiny but in ourselves.â⬠ââ¬â¢ William Shakespeare My decision to pursue my Masters in Germany is underscored by my ardent desire to be enrolled in Masters at your esteemed institution. TU Munchen offers ample opportunities to excel in fields of engineering. In the changing world of science and technology everybody tries to be perfect, knowledgeable and expert in his/her field. Like many others, the thirst and quench of getting more and more knowledge also kept me motivated to follow my ambition. I was always fascinated with buildings (residential and commercial). The thought that how they are made and what makes them strong enough to support huge weights kept me thinking. This interest made me chooseâ⬠¦show more contentâ⬠¦Plain Reinforced Concrete and Reinforced and Prestressed Concrete made my concepts clear about significance of concrete in structures. Estimation Quantity surveying assisted me in perceiving principle knowledge about costing and quality control. And to boost up my abilities Construction Management featured importance of management, team work, coordination and team lead for project execution. During my 3rd year of the degree I got an internship for 4 weeks with the best organization related to construction NESPAK. I worked in Construction Management division of NESPAK at Aashiana Housing society project. For the first time, I learnt how quality control of materials is carried out to ensure safety and efficient construction. After that I joined MAAKSONS as an internee. I worked in Architecture division and worked as an Architect engineer on different projects (Houses, Badminton court, Squash court, Basketball court, Hospital) and also visited site to have my vision broadened. After completing my Bachlors I got a chance to work in S.K.B as a Site Engineer at METRO (BRTS Package II b) project initiated by Chief Minister of Punjab. I was exposed to modern construction methods, management and use of modern equipments. It enhanced my structural knowledge in Bridges and Roads as well as regarding execution and team work. After SKB I got an opportunity to work in EngineeringShow MoreRelatedWilliam Shakespeare s Romeo And Juliet1779 Words à |à 8 Pagesand Juliet Final William Shakespeare once said ââ¬Å"It is not in the stars to hold our destiny, but in ourselves.â⬠This quote means people are self-determined, there is no such thing as a predetermination. You are not ââ¬Å"fatedâ⬠to a particular result. This is not to say that somebody s circumstances (born into wealth or poverty) do not have a major impact on your life. It is not up to fate to decide what happens to someone, but it is someone s choices and decisions in their lives that will determineRead More edmundlear Edmund of King Lear as Nietzsches Free Spirit Essay2780 Words à |à 12 PagesEdmund of King Lear as Nietzsches Free Spirit à à à à à In King Lear, Shakespeare creates a brilliant tragedy whose plot is driven primarily by its villains. Of these, Edmund stands alone as a man who makes his fortune, surrounded by those who seize fortune only when it is handed to them.à Shakespeares ability to create a vivid, living character in the space of a few lines of speech triumphs in Edmund, who embodies a totally different moral system than that of Shakespeares era.à Three centuriesRead MoreEssay on Elder Scrolls III:Morrowind3837 Words à |à 16 Pagesnegative behavior. Your game playââ¬âthe narrative possibilities available to you, and the ones you actually takeââ¬âchanges and evolves depending on how your character acts, and other charactersââ¬â¢ expectations about how s/he will act. In Morrowind, our characterââ¬â¢s role in the game, and thus, the narrative paths that s/he can take, is shaped by us, his/her interactions with others in the virtual world of Morrowind, and their expectations of him/her based on the role s/he inhabits. To properly createRead MoreGender Roles and Attitudes toward Love in Shakespeares Hamlet5989 Words à |à 24 PagesRomeo and Juliet is a heart-breaking tragedy written early in the career of playwright William Shakespeare telling us the story of two teenage ââ¬Ëstar-crossââ¬â¢d loversââ¬â¢ whose unfortunate deaths ultimately unite the dispute between their two families. Despite the perils involved, they fall in love and marry with the help of two characters, Friar Lawrence and the Nurse. Throughout the play, Shakespeare portrays a range of different kinds of love through the central female characters. Maternal love is offeredRead MoreLogical Reasoning189930 Words à |à 760 Pagesattract readers. Stanley Baronett. Jr., University of Nevada Las Vegas Far too many authors of contemporary texts in informal logic ââ¬â keeping an eye on the sorts of arguments found in books on formal logic ââ¬â forget, or underplay, how much of our daily reasoning is concerned not with arguments leading to truth-valued conclusions but with making choices, assessing reasons, seeking advice, etc. Dowden gets the balance and the emphasis right. Norman Swartz, Simon Fraser University v Acknowledgments Read MoreDeveloping Management Skills404131 Words à |à 1617 PagesSensitive Line 58 Understanding and Appreciating Individual Differences Important Areas of Self-Awareness 61 Emotional Intelligence 62 Values 65 Ethical Decision Making and Values 72 Cognitive Style 74 Attitudes Toward Change 76 Core Self-Evaluation 79 SKILL ANALYSIS 84 Cases Involving Self-Awareness 84 Communist Prison Camp 84 Computerized Exam 85 Decision Dilemmas 86 SKILL PRACTICE 89 Exercises for Improving Self-Awareness Through Self-Disclosure 89 Through the Looking Glass 89 Diagnosing ManagerialRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words à |à 1573 PagesPreface xxii 1 2 Introduction 1 What Is Organizational Behavior? 3 The Individual 2 3 4 5 6 7 8 Diversity in Organizations 39 Attitudes and Job Satisfaction 69 Emotions and Moods 97 Personality and Values 131 Perception and Individual Decision Making 165 Motivation Concepts 201 Motivation: From Concepts to Applications 239 3 The Group 9 10 11 12 13 14 15 Foundations of Group Behavior 271 Understanding Work Teams 307 Communication 335 Leadership 367 Power and Politics 411 ConflictRead MoreManagement Course: MbaâËâ10 General Management215330 Words à |à 862 Pageseffects, innovation might not have taken place at all. All this business growth has caused increasing complexity in business action and decision making. It has presented chief executive officers (CEOs) and management leaders in all markets and industries with new intricacies in deciding how to weigh and time the business decisionsââ¬âand the quality of those decisionsââ¬âthat increasingly challenge their companiesââ¬â¢ basic survival. W HICH FACTORS HAVE DRIVEN 3 4 FeigenbaumâËâFeigenbaum: TheRead MoreOrganisational Theory230255 Words à |à 922 Pages. Organization Theory Challenges and Perspectives John McAuley, Joanne Duberley and Phil Johnson . This book is, to my knowledge, the most comprehensive and reliable guide to organisational theory currently available. What is needed is a text that will give a good idea of the breadth and complexity of this important subject, and this is precisely what McAuley, Duberley and Johnson have provided. They have done some sterling service in bringing together the very diverse strands of work
Tuesday, May 5, 2020
Generation Diversity for Culture and Gender - myassignmenthelp.com
Question: Discuss about theGeneration Diversity for Culture, Background and Gender. Answer: Introduction: Workplaces these days are experiencing so much of diversity. Diversity at the workplace can be because of the culture, background, gender etc. there is one of major factors that also affect the diversity at the workplace and that factor is generation. This is the factor that is very much under studied by the researchers. It has been analysed that generational gaps between the employees at the workplace is beneficial as well as provides many disadvantages to the company. These challenges need to be managed and faced by the management of the company (Yusoff and Kian, 2013). There are basically there types of generations that are baby boomers, generation X and generation y. this is the report that focuses on generation X and their characteristics. Purpose: The purpose of the report is to analyze the characteristics of the generation X employees at the workplace. It also focuses on the study of their communication pattern and their way of working at the organizations. Generation X Who we are: These are the people who were born in the year of 1961 to 1976. The group of generation X people shows the culture of 70s are generally referred to as the Latch Key kids. Generation X follows the generation of baby boomers and is prior to the generation of millennial. They are the one who constitutes most of the percentage of the jobs these days in the organizations. In terms of work the people that falls under this category are committed to their work rather their company (Mencl and Lester, 2014). They believe in growth and exploring the new opportunities for them and work hard till that the time it is needed. Along with the responsibilities, they also want authority from the company and also believe in making friendly conversations with the superiors. They expect from the organizations that their opinion should be considered at the time of making any of the decisions they are the one who gets affected by the organizational decisions (Costanza and Finkelstein, 2015). Xers perform ve ry well when they are given with some of the goals but not the process to complete it. They cant work in the bounded environment and little bit of freedom to make decision over the process and the working style is required by them to perform efficiently (Barak, 2016). The people of generation X are very much independent in nature and thus like to work in their own way. Work life balance: Work life balance is the concept that is very popular these days. It has been analyzed that this is the aspect that deals with maintaining balance between the work and the life of the people. This maintenance can be done if the companies or the management helps the employees as well as it depends on the individual itself. It has been identified that difference in generation affect the perspective of the employees regarding work life balance. When the baby boomers are concerned there was so much in work that they have forgotten to make a balance and till now they are behaving like that. It has been analyzed that generation X has different expectation from the company (Becton, Walker and Jones?Farmer, 2014). They know their one worth and thus have the capability to fight for their rights. Researchers suggest that work life balance is majorly enjoyed by the generation because they are the people who does not expects a lot from the organizational but also focuses on getting the facilitie s that should be there or that should allow them to manage their work and personal life as well. Generation X people are very confident enough and focused on their work but not committed too much with the organization. Thus, if they get better policies in anther organization, they do not think of switching from one company to another in order to balance their life. Communication: As far as the communication in generation is considered, it has been analyzed that most of the people from this generation are blunt but not manner less. They know the code of conduct to talk from the superior employees but never afraid to putting their points in front of the management. E-mail is one of the tools that have been used by the Xers to communicate in the offices either with their colleagues or with their managers (Maxwell and Broadbridge, 2014). This is because they find it very easy and a formal method of communicating with others. They are the one who are in between baby boomers and millennial thus they have little bit understanding of both the generation and thus the communication of these Xers is found to be best. They can relate to baby boomers in some of the points and can also relate to millennial in some of the points. This also helps them to be very adaptive in nature. They can adapt the changes happening in the environment very early (Bueno, Jin and Wong, 2014) . They very well know that where they have to be formal and where they have to use the informal tone to talk. They are not very much full of desires but they fight for their rights with full zeal. Recommendations: There are several recommendations that have been given to the company in order to deal with generation X people. As discussed that Xers are very much independent thus it is required to create the workplace environment such that allow the employees to take part in the decision making process so that they can share their ideas and opinions to the management (Lyons and Kuron, 2014). It is very much required to provide facilities and equality to the workers so that they feel motivated to stay in the organizations implementation of some of the motivation theories and practices in the organization helps in this (Seipert and Baghurst, 2014). Work life balance is the very important part of their life.it is required by the company to provide them work life balance and also provide the opportunities to these employees to grow in order to retain them in the company. Conclusion: To conclude, it can said that Xers are the people who are very much dedicated towards their work but are not committed to the companies they work with. This is because they are ambitious in nature and wants to grow and wants to explore the opportunities available to them. It has been analyzed that they are the one who enjoys work life balance at the most because they fight for their right and also wants to live their life along with having growth in the professional life. Work life balance allows these people to manage their life and their work and thus they remain happy. They feel pressurized because of managing both types of life. They use e-mails and the formal communication method and know how to communicate with management and with colleagues. They form the bridge between baby boomers and millennial. References: Barak, M.E.M., 2016.Managing diversity: Toward a globally inclusive workplace. Sage Publications. Becton, J.B., Walker, H.J. and Jones?Farmer, A., 2014. Generational differences in workplace behavior.Journal of Applied Social Psychology,44(3), pp.175-189. Bueno, P.M., Jino, M. and Wong, W.E., 2014. Diversity oriented test data generation using metaheuristic search techniques.Information Sciences,259, pp.490-509. Costanza, D.P. and Finkelstein, L.M., 2015. Generationally based differences in the workplace: Is there a there there?.Industrial and Organizational Psychology,8(3), pp.308-323. Lyons, S. and Kuron, L., 2014. Generational differences in the workplace: A review of the evidence and directions for future research.Journal of Organizational Behavior,35(S1). Maxwell, G.A. and Broadbridge, A., 2014. Generation Y graduates and career transition: Perspectives by gender.European Management Journal,32(4), pp.547-553. Mencl, J. and Lester, S.W., 2014. More alike than different: What generations value and how the values affect employee workplace perceptions.Journal of Leadership Organizational Studies,21(3), pp.257-272. Seipert, K. and Baghurst, T., 2014. Contrasting work values of Baby Boomers and Generation X rural public school principals.Public Administration Quarterly, pp.347-370. Yusoff, W.F.W. and Kian, T.S., 2013. Generation differences in work motivation: From developing country perspective.International Journal of Economy, Management and Social Sciences,2(4), pp.97-103.
Friday, April 17, 2020
The Tragedy of Macbeth Essay Summary Example For Students
The Tragedy of Macbeth Essay Summary Macbeth is a story about Good versus Evil on one mans mind. It is a tail about how a brave and intelligent man deliberately murders one of his fellowmen: his friend, his relative, his guest, and his king; as a consequence of his first murder, kill two other innocent men. Macbeth has lust for power and brings absolute destruction on himself and his family. When he cannot turn away from his evil course, it leads him to further appalling crimes and finally to disgrace, alienation, isolation, despair, and a violent death. In Act, one Scene 3, three witches are talking to Macbeth. Macbeth is not quite sure what to think of these prophesies-whether they are good or bad-and struggles with their possible significance. At this point in the play, Macbeth is good nature and finds his thoughts of murder. His mind focuses less on the reality of the present and focuses more on the possibilities of the future, thus his ambition takes over and becomes the single driving force in his life. Macbeths conscious is raising serious doubts as to whether or not he should kill Duncan. We will write a custom essay on The Tragedy of Macbeth Summary specifically for you for only $16.38 $13.9/page Order now He is worried not only that he may make a mistake and ruin his chance of attaining the throne, but also that Duncans virtues arouse so much pity that damnation will come upon his murderer. Macbeth is definitely not comfortable with killing Duncan. Finally, he recognizes his ambition, and the fact that it may cause him to falter. Act two Scene 1 Macbeths inner struggle and mental anguish is so great that he is now hallucinating, as he sees a dagger before him. He realizes that this dagger is a product of his feverish mind. At this point in the play, evil thoughts and deeds horrify Macbeth. This is shown when the imagined dagger returns, with blood on it. Lady Macbeth says that the alcohol that made the attendants drunk has given her courage. Omens of death wish the king a good night, and Macbeth is going to kill him, as the drunken attendants are unconscious. When Macbeth shows up, she is afraid they woke up and it did not work. She would have done it if Duncan did not look like her fate. Macbeth did it though (killed him). One attendant woke up and said Murder but then they went back to sleep. In Act IV, Scene 2 Lady Macduff is wondering why her husband left. She thinks he was mad, looking like a traitor, loveless and cowardly to leave his family and possessions. Ross tries to comfort her, telling her he knows what is wrong at that moment. Lady Macduff has an interesting conversation with her son Sirrah about what they will do without a father. The messenger tells her to leave, that she is in danger. Lady Macduff does not know where to go, and she has done no wrong. As she realizes that doing well is sometimes a bad thing. The murderers arrive kill the son, but Lady Macduff escapes. Act V, Scene 3 Macbeth is wondering how the prophecy will come true, and tries to remain confident. Macbeth comforts his servant for seeming afraid but is told of the English forces. Macbeth tells Seyton this revolt will either remove or leave him happy, as right now he has none of things due a man of old age. Macbeth asks for his armor, planning to defend himself to the end. Macbeth asks the doctor to cure his wife. The doctor wishes he were not there. Malcolm hopes to regain the safety they once had. Menteith is sure it will happen. Malcolm tells each soldier to cut down a large tree branch and put it in front of him, thereby camouflaging himself. The scouts will think there are less of them that way. Macbeth waits in his castle, his only hope of defense. Though they have hopes of what they want to accomplish, now is the time for actual blows and battle to win. Macbeth says let them come to the castle; he can hold them off. If they did not have his soldiers, then he could have met them on the field and beat them back. .u8b6aaa3f8f29902a7a2a084020ff66ed , .u8b6aaa3f8f29902a7a2a084020ff66ed .postImageUrl , .u8b6aaa3f8f29902a7a2a084020ff66ed .centered-text-area { min-height: 80px; position: relative; } .u8b6aaa3f8f29902a7a2a084020ff66ed , .u8b6aaa3f8f29902a7a2a084020ff66ed:hover , .u8b6aaa3f8f29902a7a2a084020ff66ed:visited , .u8b6aaa3f8f29902a7a2a084020ff66ed:active { border:0!important; } .u8b6aaa3f8f29902a7a2a084020ff66ed .clearfix:after { content: ""; display: table; clear: both; } .u8b6aaa3f8f29902a7a2a084020ff66ed { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u8b6aaa3f8f29902a7a2a084020ff66ed:active , .u8b6aaa3f8f29902a7a2a084020ff66ed:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u8b6aaa3f8f29902a7a2a084020ff66ed .centered-text-area { width: 100%; position: relative ; } .u8b6aaa3f8f29902a7a2a084020ff66ed .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u8b6aaa3f8f29902a7a2a084020ff66ed .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u8b6aaa3f8f29902a7a2a084020ff66ed .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u8b6aaa3f8f29902a7a2a084020ff66ed:hover .ctaButton { background-color: #34495E!important; } .u8b6aaa3f8f29902a7a2a084020ff66ed .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u8b6aaa3f8f29902a7a2a084020ff66ed .u8b6aaa3f8f29902a7a2a084020ff66ed-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u8b6aaa3f8f29902a7a2a084020ff66ed:after { content: ""; display: block; clear: both; } READ: Much Ado About Nothing - Do Men In The Play Hate Or Love The Women? EssayMacbeth has forgotten what it is like to be afraid; having as much fear as a man can bear. Macbeth wishes his wife had died later, at a better time. He comments on how life passes at this little speed, with people dying after a futile life. Macbeth says the messenger comes to speak. He should give his report quickly. The messenger, unsure of how to report what he saw, says Birnham wood appeared to move, thus the prophecy is fulfilled. Macbeth starts wishing this were just all over and prepares for death fighting. Macbeth knows he is stuck fighting, and he wonders who was not born of woman. Macbeth tell Young Siward who he is, and Macbeth says he should be not just hateful but fearful to Young Siwards ears. Macbeth says he does not fear any not of woman born and kills Young Siward. Macduff says he must kill Macbeth to avenge his family, and only Macbeth. By the noise of Macbeths armor, he locates him. Siward explains the battle is easy. Malcolm enters the castle. Macbeth asks why he should kill himself when the wounds he might inflict upon himself would look better upon his living enemies. Macbeth says he has avoided Macduff and does not want to kill him after killing his family. Macduff says he will speak with his sword instead of words. Macbeth says that Macduff will not hurt him. Macduff then reveals that he was ripped from his mothers womb while she died. Macbeth is angry to discover that the prophecy will come true and only provided him false hope. Macduff tells him to give up and explains he will be put on a pole and displays as a tyrant. Macbeth says he will try despite the prophecy rather than yield to Malcolm. Malcolm wishes no one had to die, but Siward says it is necessary and the cost was not that high for such a good day. Ross tells Siward that Young Siward, who just became a man in fighting, died. He tells him not to have sorrow, though. Siward says he died well. Macduff hails Malcolm as king holding Macbeths head. Although Macbeth started out as a good character evil became a factor. He listens to the prophecy and not to his heart, which lead him in the wrong direction. Power is a big factor through the whole play. That is all the characters fight about, and in the end, Malcolm becomes king and Macbeth losses his head. Therefore, which is more important, power or your life That is for you to decide.
Saturday, March 14, 2020
Waiting for Social Security Disability
Waiting for Social Security Disability Social Security Disability: The Ultimate Waiting Game The process for Social Security Disability is not an easy one, and it certainly is not fast. At the initial application level there are very low approval rates, extremely over-worked Social Security employees, and incredible hardships faced by the claimants. All of this mixed together results in a frustrating experience for the person who is trying to secure an income to help their family.One of the hardest parts of the entire process is the waiting. You canââ¬â¢t work, you have no income, the bills are piling up, and there are notices coming in almost weekly. It seems like there is no end in sight.After you submit your request for a hearing, the biggest wait time begins. The wait times for a hearing vary between each office. Here are Michiganââ¬â¢s hearing offices and their average wait times for cases that were heard in September, 2016:Detroità 15 monthsFlintà 18 monthsGrand Rapidsà 18 monthsLansingà 17 monthsLivoniaà 13 monthsMt. Pleasantà 19 monthsOak Parkà 16 monthsIn comparison, the shortest waiting period belongs to Fort Smith, AR at 8 months, and the longest waiting period is in Ponce, Puerto Rico at 27 months (25 months in Buffalo, NY is the highest for states). The average wait time for all of the hearing offices is 17.7 months which shows that Michigan is experiencing roughly average wait times.One of the biggest contributing factors is the huge backlog of cases. Since there is such a low approval rating on the initial applications, there is a huge number of people filing appeals. The more people with appeals pending in a certain area, the longer the wait time.There is a light at the end of the tunnel though. For the 2016 fiscal year, more hearings were heard than scheduled.If you are finding yourself in a hardship situation, you may be able to speed up your case. This is never guaranteed, and there are no definite set of guidelines for approval, but it is always worth a shot.Additionally, if you need help with food, bills, or gen eral living expenses, please check out the Resources area of our website, contact the United Way at 411, or look into local charities and churches.
Wednesday, February 26, 2020
Obama's position Assignment Example | Topics and Well Written Essays - 250 words
Obama's position - Assignment Example Thirdly, a nationââ¬â¢s secrets are vital since they will play a fundamental role in shaping the efficacy of security controls and measures set by the government. If the secrets are given to the public, it implies that the terrorists will be aware that their links are being monitored, and this may undermine security. Therefore, the presidentââ¬â¢s position to order killing of someone who is a threat to security without disclosing the reason is good because it will tighten the security measures by preserving the nationââ¬â¢s secrets of the nation. However, there are arguments against this stand first because human rights ought to be emphasized and no one should have the sole right of determining another personââ¬â¢s destiny. Secondly, the United States constitution provides for fair trial of any person accused of crime and imposing death implicitly is going against the constitution. Thirdly, the President ordering the killing of a United States citizen or any other person could have political reasons, and this means that it would not be fair if the suspected person were not tried in the courts to determine the viability of the claims placed against
Monday, February 10, 2020
G Protein Coupled Receptor Function in Bipolar Disorder Type Research Proposal
G Protein Coupled Receptor Function in Bipolar Disorder Type - Research Proposal Example The paper tells that bipolar disorder is a complex psychiatric disease having genetic basis. This is mainly due to the chemical imbalance bipolar disorder affects up to 3 percent of the total population. According to World Health Organization report of 2001, bipolar disorder stands fifth for the cause of disability among the adults. Male and female are affected by this disease in equal ratio. This disease can develop at any age and takes several years for complete development in the individual. Bipolar disorder is a family disease. It is the combination of stigma, disability and cognitive impairment. Depression causes the emergence of this disease in people. The lacks of neurotransmitters at the brain are found to be associated with the bipolar disorder. The symptoms of bipolar disorder are elevated mood, different thoughts, pressurized speech, less need for sleep, increase in the goal directed activity, poor judgment and tangential speech. Bipolar disorder is associated with long te rm morbidity, co morbidity, disability and increased mortality rates due to suicide accidents etc. G- Protein coupled receptors (GPCRs) comprises a super family of cell membrane receptors with many common features having a single polypeptide with many membrane spanning domains. GPCRS have seven transmembrane proteins with hetero-trimers. There is an alpha sub unit which binds to guanine nucleotides. GPCRs play important role in the development and regulation of cellular physiology. They participate in the diversified physiological functions and are the targets of many drugs. The ligands are very diverse such as amides, peptides, proteins, lipids, nucleotides and photons. GPCRs have many alternating signalling pathways and interact mainly with the proteins such as arrestins and kinases. 90% of the nonsensory GPCRs are present in the brain and they play many important neuronal functions. There are five dopamine receptors D1, D2, D3, D4 and D5 divided into two groups based on the seque nce and functional similarities. D1 like (D1 and D5) and D2 like (D2, D3, D4). (Pompili et al., 2011).These dopamine receptors are believed to be involved in the brain disorders such as Parkinsonââ¬â¢s disease, schizophrenia, addiction, and Huntingtonââ¬â¢s disease. The D4 receptor is activated by the dopamine receptor present in the brain. The mutations in the GPCRs have resulted in a number of diseases in human. The mutations may be activating mutations or inactivating mutations. D1, D2 are shown to have a greater interaction with the bipolar disorder. All the antipsychotic drugs block the dopamine D2 receptors and are
Thursday, January 30, 2020
Literature Paper Essay Example for Free
Literature Paper Essay Sophocles two plays, namely the AD 6717-658 Oedipus the King as well as the 658-693 Antigone, are dominated by elements of conflict both external and internal. The external conflict involves two persons with opposing viewpoints being engaged in a physical or philosophical confrontation. On the other hand, the internal cases of conflict occur when certain individuals in the 2 plays encounter dilemmas regarding doing things that their consciences counsel against. Further, the playwright describes various characters handling the conflicting situations in a variety of ways. For example, some characters just choose to give in, become complicit, and do the things that their consciences advise against. A notable example of this phenomenon in Oedipus the King is Queen Jocastaââ¬â¢s action of bowing to King Laiusââ¬â¢ (her husbandââ¬â¢s) pressure and thus giving away the young Oedipus to be disposed off. Likewise, in Antigone, Ismene depicts the same behavior of allowing outside pressure to adversely influence her conscience-led aspirations. To this end, Ismene refuses to join efforts with Antigone her defiant sister in burying Polyneices the 2 sistersââ¬â¢ departed brother. Conversely, the 2 plays contain cases whereby physical person-to-person conflicts arise. For instance, in Antigone, Creon Thebeââ¬â¢s ruler holds viewpoints that conflict with those of Haemon Creonââ¬â¢s son. To illustrate, when Creon detains and intends to murder Antigone Haemonââ¬â¢s fiance son and father are at loggerheads. The situation deteriorates to the extent of father and son insulting one another. Haemon angrily leaves, promising that he will never come back. Similarly, in Oedipus the King, King Oedipus becomes conflicted with prophet Tiresias because Tiresias is experiencing an internal sort of conflict. The prophet is aware that telling King Oedipus the truth about who killed King Laius would yield no good results. On the other hand, King Oedipus is very intent on ascertaining the true identity of Lauisââ¬â¢ killer, not knowing that Oedipus himself killed Laius. The conflict between the 2 personalities pushes them to exchange harsh words. This conflict is resolved when Tiresias utters the definitive paradox that Laius was indeed killed by his (Laiusââ¬â¢) son. All in all, through the two plays Antigone and Oedipus the King, playwright Sophocles describes both external and external cases of conflict, with the conflicts being resolved to the detriment of a certain individual. To begin with, Queen Jocastaââ¬â¢s conflict regarding either disposing off or saving the life of Oedipus her son ends with the infant son being disadvantaged when he is disposed off. The hopeless Oedipus passes from the hands of Jocasta, to a servant, to a lowly shepherd and eventually to a Kingââ¬â¢s palace. Through such transition, the baby encounters various hardships. Firstly, he risks being killed and then spends some time out in the open fields where he is exposed to the elements. Further, it is notable that the shepherd who eventually passes Oedipus on to King Polybus has no means of keeping and raising the condemned child. Jocastaââ¬â¢s indecisiveness when she faces the internal conflict of either saving or killing Oedipus thus causes the son immense problems. In this case, Sophocles describes a conflict being resolved to the detriment of a particular personality Oedipus. In a similar version, in Antigone, Sophocles describes Antigoneââ¬â¢s conflict as resulting in a string of misfortunes. After Creon the King unjustly orders that Polyneices should be ignored regarding proper burial, with Eteocles being accorded a fitting send-off, Antigone Polyneicesââ¬â¢ sister becomes mentally conflicted. Antigone immediately detects Creonââ¬â¢s partiality in ordering for this obviously discriminative treatment. She thus cannot demonstrate complicity by adhering to Creonââ¬â¢s unjust edict. The determined girl therefore opts to secretly accord Polyneices a proper burial. By doing this, Antigone risks being put to death as indicated by Creonââ¬â¢s directive. She however gallantly carries on with her plan and even boldly defending her decisions before the King. Related to Antigoneââ¬â¢s mental conflict is Ismeneââ¬â¢s dilemma whereby she has to choose to either stand by Antigone or obey Creonââ¬â¢s controversial decree. By adhering to the directives that Creon has issued, Ismene will in effect be betraying Polyneices her brother. Conversely, by deciding to join Antigone in properly burying Polyneices, Ismene will be showing sisterly responsibility to her departed brother as well as to Antigone. In addition, Ismene risks being put to death as per Creonââ¬â¢s orders should she go by Antigoneââ¬â¢s bold decision. Eventually, Ismene shies away and avoids going by Antigoneââ¬â¢s plans. On her part, Antigone boldly accords Polyneices a proper send-off, thus attracting Creonââ¬â¢s wrath. Ultimately, the 2 sisters find themselves behind bars, with Ismene being a sort of martyr since she did not participate in Antigoneââ¬â¢s defiant actions. It is at this point that Antigone faces another conflict when Ismene offers to suffer the consequences of Antigoneââ¬â¢s actions. Antigone is aware that it would be unjust to allow Ismene suffer the same fate as Antigone. Although outside pressure eventually forces Creon to let the 2 girls walk free, the conflict that Ismene and Antigone face is resolved with disastrous results. Further, the decision that Antigone makes because of being mentally conflicted serves to make Creonââ¬â¢s son Haemon to also become conflicted. To illustrate, after Creon puts Antigone in prison, intending to kill the girl, Haemon intervenes, trying to persuade Creon to let the girl walk away. Haemon does this because he is an intimate friend to Antigone. He thus cannot allow his father to kill Antigone owing to the love that Haemon has for Antigone. It is worth noting that Haemon is in a tight spot when he approaches Creon, persuading the King to let Antigone go away. This is because Haemon risks being branded a traitor or someone who demonstrates insubordination towards the King. On the other hand, should Haemon decide to keep quiet, allowing the King to do as he wills with Antigone, Haemon will demonstrate lack of commitment towards Antigone. Son and father thus confront each other because they hold varying viewpoints about the incarceration of Antigone. Again, Sophocles describes a person-to-person conflict being resolved in a negative way. After Haemon and Creon hurl insults at each other, Haemon walks away, promising that he will never come back. True to his words, Haemon commits suicide. Likewise, through the Oedipus the King play, Sophocles describes the shepherd who witnessed King Laiusââ¬â¢ murder as well as Oedipus as being conflicted both externally and internally. For instance, King Oedipus desires to know every detail of his (Oedipusââ¬â¢) childhood. On the other hand, the shepherd is aware that should he become aware of his past, Oedipus will only experience pain. The shepherd thus only gives certain details of Oedipus childhood after which he begs to be allowed to stop the narration. By doing this, the shepherd seeks to shield Oedipus from the pain that will inevitably result when the King learns of his (the Kingââ¬â¢s) past. Such good intentions are however misunderstood by Oedipus as the shepherdââ¬â¢s demonstration of insubordination. Consequently, Oedipus threatens the shepherd with death should he hold back any information from the King. The shepherd is thus deeply conflicted. He is very sure that when Oedipus learns the truth about Oedipusââ¬â¢ lineage, the King will surely be gravely hurt. Out of fear for his life, the shepherd finally explains all the details about Oedipus life. Consequently, the King becomes distraught. Further, the Queen commits suicide, after which Oedipus gorges out both his eyes and goes into self-imposed exile. Once more, Sophocles describes the conflict between the shepherd and King Oedipus as being resolved in a bad manner as it results in the deaths of Queen Jocasta and the self-imposed exile of King Oedipus. In conclusion, though his 2 plays Oedipus the King and Antigone playwright Sophocles describes numerous instances whereby various characters are conflicted either externally or internally. One notable case of mental conflict in Antigone is the instance when Antigone has to choose to either remain loyal to Polyneices her brother or obey Creonââ¬â¢s dictatorial decree. Conversely, the instance when Creon and Haemon exchange bitter words denotes external conflict. On the other hand, in Oedipus the King, Jocastaââ¬â¢s indecision regarding whether to dispose off or save Oedipus represents internal conflict. The shepherd and Oedipusââ¬â¢ confrontation demonstrates external conflict. Further, all the conflicts that are presented in both Oedipus the King as well as in Antigone are resolved in ways that harm certain characters.
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